لیست اخبار صفحه :1
Genomic and transcriptomic analysis of uterine corpus endometrial carcinoma: immune Modulation, prognostic Biomarkers, and somatic alterations

Genomic and transcriptomic analysis of uterine corpus endometrial carcinoma: immune Modulation, prognostic Biomarkers, and somatic alterations

Endometrial carcinoma (EC) represents the most prevalent gynecologic malignancy in developed countries and continues to pose significant clinical challenges. Despite favorable prognoses for patients diagnosed at early stages, high-grade and recurrent EC subtypes are associated with adverse outcomes and limited therapeutic options. In this study, we performed a comprehensive integrative analysis of uterine corpus endometrial carcinoma using transcriptomic and genomic data from The Cancer Genome Atlas (TCGA-UCEC) cohort. Analyses were conducted using R software employing DESeq2 for differential expression, clusterProfiler for functional enrichment, msigdbr for apoptosis-related gene, maftools for somatic mutations, and Cytoscape for regulatory network visualization. We identified 1,232 mRNAs, 531 lncRNAs, and 3 miRNAs significantly dysregulated in tumor tissues. Functional enrichment revealed prominent dysregulation of pathways involved in cell cycle control, apoptosis, immune modulation, and tissue-specific bi